Protein Details: Neuronal acetylcholine receptor subunit alpha-3

Protein ID

ICDB_Pro_0480

Protein Name

Neuronal acetylcholine receptor subunit alpha-3

Gene Name

CHRNA3; NACHRA3

Organism

Homo sapiens (Human)

Length

505 amino acids

AlphaFoldDB

AF-P32297-F1-model_v4.pdb

Function

After binding acetylcholine;the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

Sequence

MGSGPLSLPLALSPPRLLLLLLLSLLPVARASEAEHRLFERLFEDYNEIIRPVANVSDPVIIHFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMTRPTSNEGNAQKPRPLYGAELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFSANLTRSSSSESVDAVLSLSALSPEIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFLWVFTLVCILGTAGLFLQPLMAREDA

PDB Structures

4ZK4 5SYO 5TVC 6PV7 6PV8

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Bladder Dysfunction;Autonomic;With Impaired Pupillary Reflex And Secondary Cakut and Smoking As A Quantitative Trait Locus 3

Location

DOI ID

10.1073/pnas.89.5.1572; 10.1007/bf02736842; 10.1016/s0014-5793(96)01383-x; 10.1101/gr.2596504; 10.1038/452537a; 10.1038/nature06885; 10.1038/ng.109; 10.1111/jnc.13718

RefSeq

NP_000736.2